新藥研發

 
[研發] [篩選] [毒理] [技術] [文獻]

研發

RxList: The Internet Drug Index
Drug discovery online: Drug serach engine
Center for Drug Evaluation and Research: U.S. Food and Drug Administration
Europort:Structure-based drug design at EMBL and Merck
Developmental Therapeutics: NCI/NIH program
Molecular Design Institute:Structure-based drug design at Univ of Cal at SF
NIH-Drug Discovery Group:National institutes of health drug discovery
Structural Bioinformatics: Genes to Drug Lead
3D Pharmaceuticals: Structure-Based Drug Design

篩選

The NCI Drug Information System 3D Database: The NCI DIS 3D database is a collection of 3D structures for over 400,000 drugs.
Cyberbotanica: Plants and Cancer Treatment
Developed by Lucy Snyder of BioTech, this mini-textbook chapter on medical botany will teach you about the various botanical compounds currently used in cancer treatment and about the plants that produce them.

3-D Structure Database of Chemicals With Pharmaceutical Activity - a database of over 400 3-D molecular structures. It is browseable alphabetically or searchable by name. Along with the models, which you can rotate or change the display mode, the database also gives you the IUPAC name and the molecular weight of the compound.

CenterWatch - a huge clinical trials listing service.

PharmInfoNet's Drug Database - a very large database of all sorts of pharmaceuticals.

Dr. Bob's Psychopharmacology Tips - an excellent, interesting site of advice and tips about prescribing a wide range of psychiatric medications. The tips are searchable, and are mainly generated from discussions on a psycho-pharm mailing list.

Drug InfoNet - contains information on pharmaceuticals and drug interactions, disease descriptions, health care news, and links to a wide range of related resources. The amount of information available on drug information alone is impressive. Detailed on-line documents, complete with drug structures, dosage, clinical trial information, and much more are easily accessible using the search engine.

Drugtext USA Homepage - a comprehensive site of information on all types of drugs, including news related to drug issues, treatment of drug addictions, legal issues, drugs in other countries and much more.

Glaxo Wellcome Pharmacology Guide - offers information relating to, among other things, the molecular basis of drug action (including sections on receptor subfamilies, G-proteins and ion channels), neurotransmitter systems and receptor binding techniques.

The Internet Drug Index - an exceedingly handy database for looking up pharmaceuticals by name or drug code. Also contains a table of information on the 200 most-prescribed medications. You can search drugs by brand or generic name, drug interaction, side effects and symtoms.

Molecular Recognition Section of the National Institutes of Health - another big meta-site with a wide range of offerings.

PCS HealthSystems Performance Drug List - the formulary for the managed pharmaceutical care organization, PCS HealthSystems. The clinical formulary is organized by sections that refer to either a drug class or disease state. Each section contains a list of frequently used therapeutic regimens. Within each list are products, their generic name or brand name, prescribing guidelines, applicable dosage forms, relative costs, and pharmacological strengths.

Pharmaceutical Information Network Homepage - this extensive and well designed page is dedicated to providing high quality scientific information about pharmaceuticals and their actions in the human body to professionals, researchers, students and the general public.

Antibiotic Guide - contains the 1997 guide to antibiotic therapy prepared for a teaching affiliate of the Medical College of Wisconsin. Includes tables of antimicrobial agents, costs, indicators, and treatment recommendations.

Drug discovery-Arris company
Drug discovery-Isis company
Cellomics: Cellomics Inc.’s mission is to improve the efficiency of the drug discovery process by delivering a cell-based screening platform that automates target validation and lead optimization using fluorescence-based assays.
General Principle of Membrane Protein Folding and Stability
Crofts Lab Home Page
The Offical Mad Cow Disease Home Page
G Protein-Coupled Receptors
UCSF: Molecular Design Institute
Metalloprotein Site Database and Browser
Polyketide Biosynthesis
Medical Microbiology
The Recombinant Antibody Page
Antibody Engineering

毒理

National Center for Toxicological Research: The mission of NCTR is to conduct peer-reviewed scientific research that supports and anticipates the FDA's current and future regulatory needs.
Anti-CancerDrug Design
Current Opinion In Immunology
European Biophysics Journal
Immunology Today
Journal of Immunology
Journal of Pharmaceutical Sciences
Protein Science
Prion Reasearch

技術

Syrrx: Structural Genomcis Comapany-X-Ray
Structural GenomiX: Structural Genomcis Comapany-X-Ray
Structural GenomiX: Structural Genomcis Comapany-Homology Modeling and Rational Drug Design

文獻

FDA-News and Publication: The Food and Drug Administration is to see that the food we eat is safe and wholesome, the cosmetics we use won't hurt us, the medicines and medical devices we use are safe and effective, and that radiation-emitting products such as microwave ovens won't do us harm. Feed and drugs for pets and farm animals also come under FDA scrutiny. FDA also ensures that all of these products are labeled truthfully with the information that people need to use them properly
Anti-CancerDrug Design
Drug discovery today
Current Opinion in Drug Discovery & Development
CDrug
European Biophysics Journal
Immunology Today
Journal of Immunology
Journal of Pharmaceutical Sciences
Protein Science
Prion Reasearch

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