學歷
1990.9~1994.6       學士         國立台灣大學  植物病理學系
1994.9~1996.6       碩士         國立成功大學  生物化學所
2000.8~2005.8       博士         美國北卡羅來納大學教堂山分校  病理所
　

經歷
2005.9~2006.8     博士後研究                          
                             美國北卡羅來納大學教堂山分校  病理學系
　

      2006.8 至今         助理教授
                             國立成功大學 臨床醫學所
　

      2006.8 至今         兼任助理教授
                             國立成功大學 生理所

得獎記錄

 1995        成功文化基金會獎學金

 1996        中華民國斐陶斐榮譽學會 榮譽會員

 2002        American Heart Association Predoctoral Fellowship (2002~04) (0215270U)

 2002        Research Presentation Award, Annual Research Symposium of Graduate Program

                  in Molecular and Cellular Pathology, UNC-Chapel Hill

 2003        National Institutes of Health Scholarship Award, Keystone Symposia

                  (1 R13 DK063898-01)

 2004        National Institutes of Health Scholarship Award, Keystone Symposia

                  (1 R13 DK067025-01)

2009       成大醫學院新人最佳論文獎

2010       成杏基金會優秀論文獎

2010       成大醫學院基礎醫學研究獎

著作 (2004 至今)

1.      M Kakoki, YS Tsai, HS Kim, S Hatada, DJ Ciavatta, N Takahashi, LW Arnold, N Maeda, and O Smithies. Altering the expression in mice of genes by modifying their 3’-regions. Developmental Cell 6, 597-606, 2004.

2.      YS Tsai, HJ Kim, N Takahashi, HS Kim, JR Hagaman, JK Kim, and N Maeda. Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARg. Journal of Clinical Investigation 114, 240~249, 2004.

3.      YS Tsai and N Maeda. PPARg: a critical determinant of body fat distribution in humans and mice. Trends in Cardiovascular Medicine 15, 81~85, 2005.

4.      YS Tsai, A Pendse, SS Moy, I Mohri, A Perez, JN Crawley, K Suzuki, and N Maeda. A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. Mammalian Genome 17, 716~722, 2006.

5.      AM Beyer, GL Baumbach, CM Halabi, ML Modrick, CM Lynch, TD Gerhold, SM Ghoniem, W deLange, HL Keen, YS Tsai, N Maeda, CD Sigmund, and FM Faraci. Interference with PPARg signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension 51, 1~5, 2008.

6.      D Meredith, M Panchatcharam, S Miriyala, YS Tsai, AJ Morris, N Maeda, GA Stouffer, and SS Smyth. Dominant-negative loss of PPARg function enhances smooth muscle cell proliferation, migration, and vascular remodeling. Arterioscler Thromb Vasc Biol. 29, 465~471, 2009.

7.      JS Wu, WM Cheung, YS Tsai, YT Chen, WH Fong, HD Tsai, YC Chen, JY Liou, SK Shyue, JJ Chen, YE Chen, N Maeda, KK Wu, and TN Lin. Ligand-activated PPAR-γ protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3ε upregulation. Circulation 119, 1124~1134, 2009.

8.      YS Tsai*, PJ Tsai, MJ Jiang, TY Chou, A Pendse, HS Kim, and N Maeda*. Decreased PPARg expression compromises perigonadal-specific fat deposition and insulin sensitivity. Mol Endocrinol. 23, 1787~1798, 2009. *Corresponding author.

9.      YS Tsai, L Xu, O Smithies, and N Maeda. Genetic variations in PPARg expression affect blood pressure. Proc Natl Acad Sci U S A. 106, 19084~19089, 2009.

10.  MC Chiang, CM Chen, MR Lee, HW Chen, HM Chen, YS Wu, CH Hung, JJ Kang, CP Chang, C Chang, YR Wu, YS Tsai, and Y Chern. Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma. Hum Mol Genet. 19, 4043~4058, 2010.

11.  AA Pendse, LA Johnson, YS Tsai, and N Maeda. Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction. Diabetes 59, 2890~2897, 2010.

12.  HY Huang, YS Tsai, JJ Lee, MC Chiang, CY Chiang, NT Lin, and PJ Tsai. Mixed Infection of Beijing and non-Beijing strains and drug resistance pattern of Mycobacterium tuberculosis. J Clin Microbiol. 48, 4474~4480, 2010.

13.  CJ Hong, PJ Tsai, CY Cheng, CK Chou, HF Jheng, YC Chuang, CN Yang, YT Lin, CW Hsu, IH Cheng, SY Chen, SJ Tsai, YJ Liou, and YS Tsai*. ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin. PLoS ONE 5, e15333, 2010.

14.  SM Chen, YS Tsai, CM Wu, LC Wu, YH Liu, and PJ Tsai. Streptococcal collagen-like surface protein 1 promotes adherence to respiratory epithelial cells. BMC Microbiol. 10, 320, 2010.

15.  LH Kuo, PJ Tsai, MJ Jiang, YL Chuang, L Yu, KT Lai, and YS Tsai*. Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse. Diabetologia 54, 168~179, 2011.

16.  YF Tu, YS Tsai, LW Wang, HC Wu, CC Huang, and CJ Ho. Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation. J Neuroinflamm. 8, 40, 2011.

17.  PH Kuo, CF Kao, PY Chen, CH Chen, YS Tsai, ML Lu, MC Huang. Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients. J Clin Psychopharmacol. 31, 705-711, 2011.

18.  HF Jheng, PJ Tsai, SM Guo, LH Kuo, CS Chang, IJ Su, and YS Tsai*. Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol. 2011. (in press)

19.  JY Chen, PJ Tsai, HC Tai, RL Tsai, YW Chiou, ML Yeh, MJ Tang, YH Li, WC Tsai, LJ Lin, HL Wu, and YS Tsai*. Increased Aortic Stiffness and Impaired Elastic Fiber Stability in Obesity. Int J Obes. 2011. (submitted)

 (* corresponding author)

受邀演講

1.      PPARgamma and the Metabolic Syndrome: Mouse Models. Institute of Molecular Biology, Academic Sinica, Taipei, Taiwan. Mar. 2005.

2.      My Journey from Plant Pathology to Animal Disease Models. Graduate Institute of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan. Nov. 2007.

3.      Designer mice for human disease - A close view of Nobel Laureate: Oliver Smithies.
   Understanding 2007 Nobel Laureate. National Cheng Kung University, Tainan, Taiwan. Nov. 2007.

4.      PPARs: Physiology, Prevention and Therapeutic Effects of its Agonists on Metabolic Syndrome and Arteriosclerosis. Symposium on PPARs and Metabolic Syndrome. National Cheng Kung University, Tainan, Taiwan. Dec. 2007.

5.      Toll-Like Reeptor in the Metabolic Disease and its Complications. Symposium on the Gene Targeting in Embryonic Stem Cells and its Effects on Biomedical Sciences. National Cheng Kung University, Tainan, Taiwan. Oct. 2008.

6.      Novel role of PPARγ in the regulation of energy homeostasis. National Research Institute of Chinese Medicine, Taipei, Taiwan. Sep. 2009.

7.      PPARg in regulation of aortic stiffness and pulse pressure. International Conference on Vascular Biology. National Health Research Institute, Zhunan, Taiwan. Oct. 2009.

8.      Obesity, Perivascular Adipose Tissue, and Aortic Stiffness. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. May. 2010.

9.      Pathophysiological investigation of PPARg. The 26^th Joint Annual Conference of Biomedical Sciences. National Defense Medical Center, Taipei, Taiwan. Mar. 2011.

10.    Interplay between Lipid Inflammation and Metabolic Disease. International Conference of Inflammation, Cancer and Metabolic Disorders. National Health Research Institute, Zhunan, Taiwan. Nov. 2011.

參與計畫

1.      YS Tsai (PI) Role of PPARgamma in the metabolic syndrome: mouse models. NSC, Taiwan. Feb, 2007~Jul, 2008.

2.      YS Tsai (PI) Mouse models for energy homeostasis control. NSC, Taiwan.  Nov, 2007~Oct, 2008.

3.      YS Tsai (PI) Role of PPARr in the blood pressure regulation using genetic mouse models. NSC, Taiwan. Aug, 2007~Jul, 2010.

4.      YS Tsai (PI) The crosstalk between lipid inflammation and metabolic pathways using gene-targeted mouse models. NHRI, Taiwan. Jan, 2009~Dec, 2012.

5.      YS Tsai (PI) Study of energy homeostasis in mouse models - The Roles of PPARg in Control of Individual Fat Mass and Functionality. NSC, Taiwan. Aug, 2009~Jul, 2012.

6.      YS Tsai (PI) Arterial stiffness: A translational research from animal model to clinical medicine - The role of PPARγ in aortic stiffness and vascular dysfunction. NSC, Taiwan. Aug, 2011~Jul, 2014.